Phenolic screening and anticancer potential of various wild savory extracts

Cancer is one of the leading causes death in our age. In addition to treatments used cancer, plants are frequently complementary or alternative approaches. Plants genus Satureja world wide for various purposes, primarily as therapies. For this purpose, study, antioxidant potential and phenolic content cuneifolia plant, which consumed a spice tea among public, its cytotoxic apoptosis-inducing effects on cancer cells were tried be revealed. The effect extracts prepared with three different solvents (methanol, ethanol water) was determined by MTT test colorectal (DLD1) promyelocytic leukaemia cell lines (HL60). Then expression levels five apoptotic gene regions (apaf-1, bax, bcl2, card4, casp3 tp53) evaluated Real-Time PCR. via DPPH test, HPLC screen substances. As result, it that have variable but positive pro-apoptotic expressions. When evaluated, methanolic extract had more radical scavenging (IC50: 105.02±0.034 µg/ml). conclusion, potentials obtained from S. plant revealed first time upon DLD1 HL60 study. This study pioneer future studies therapy. Keywords: Apoptosis; qRT-PCR; Spice; Turkey; Wild savory